Center for Clinical and Translational Science Announces Pilot Funding Recipients

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The University of Kentucky Center for Clinical and Translational Science (CCTS) Pilot Funding Program announces recipients of its most recent round of pilot funding in the Collaborative Category. The mission of the Pilot Funding Program is to offer opportunities and resources necessary to support innovative intervention and early stage and collaborative research approaches in clinical and translational studies, and to promote the development of new methodologies and tools relevant to the health challenges and disparities faced by the citizens of Kentucky, Appalachia, and other rural populations.

Since its inception in 2007, the CCTS Pilot Funding Program has provided 45 grants totaling $1.6 million. Eleven projects supported by CCTS pilot grants have subsequently earned further funding from the National Institutes of Health, bringing an additional $6.9 million of research funding to UK.

The CCTS Pilot Funding Program, which is a non-disease specific program, is itself supported by a Clinical and Translational Science Award from the National Institutes of Health.

CCTS-Markey Cancer Center Collaborative Award
(18 Letters of Intent submitted; 7 applicants invited to submit full applications)

Principle Investigator: Ren Xu, PhD
College: Pharmacy
Department/Division: Pharmacology
Title: Identify RORα as a druggable EMT suppressor

Principle Investigator: Thomas Dziubla, PhD
College: Engineering
Department/Division: Chemicals and Materials Engineering
Title: Pulmonary Targeting of Poly(curcumin PBAE) nanoparticles for the Prevention of Radiation Induced Pulmonary Fibrosis

CCTS-Barnstable Brown Diabetes and Obesity Research Center
(17 Letters of Intent submitted; 7 applicants invited to submit full applications)

Principle Investigator: Gregory Graf, PhD
College: Pharmacy
Department/Division: Pharmaceutical Sciences
Title: Ezetimibe & Urso combination therapy in the treatment of nonalcoholic fatty liver disease

Principle Investigator: Changcheng Zhou, PhD
College: Medicine
Department/Division: Graduate Center for Nutritional Sciences
Title: IKKbeta links vascular inflammation to obesity and insulin resistance

CCTS-Spinal Cord and Brain Injury Research Center
(9 Letters of Intent submitted; 6 applicants invited to submit full applications)

Principle Investigator: Lumy Sawaki, PhD
College: Medicine
Department/Division: Physical Medicine and Rehabilitation
Title: Effects of transvertebral direct current stimulation in humans

Principle Investigator: Edward Hall, PhD
College: Medicine
Department/Division: SCoBIRC
Title: Oxidative Damage and Calcium-Activated Proteolytic Biomarkers after Tramatic Brain Injury and Effects of Acute Cyclosporine

UK CCTS-University of Cincinnati CCTS
(8 Letters of Intent submitted; 4 applicants invited to submit full applications)

Principle Investigator: Sidney Whiteheart, PhD (UK)
College: Medicine
Department/Division: Molecular and Cellular Biochemistry
Principle Investigator: Alexandra Filipovich, MD (UC)
College: Medicine
Department/Division: Pediatrics
Title: Analysis of Platelet Function in Hemophagocytic Lymphohistiocytosis

CCTS-University of West Virginia
(7 Letters of Intent submitted; 3 applicants invited to submit full applications)

Principle Investigator: Scott Roth, MD (UK)
College: Medicine
Department/Division: Surgery
Principle Investigator: Bryan Richmond, MD (UC)
College: Medicine
Department/Division: Surgery
Title: Randomized Controlled Trial of Nonoperative Treatment Versus Laparoscopic Cholecystectomy for Gall bladder Dyskinesia

CCTS-Marshall University
(9 Letters of Intent submitted; 3 applicants invited to submit full applications)

Principle Investigator: Maria Serrat, PhD
College: Medicine
Department/Division: Anatomy and Pathology
Title: Temperature enhanced bone elongation in growth plates

CCTS Drug Discovery and Development
(21 Letters of Intent submitted; 6 applicants invited to submit full applications)

Principle Investigator: Vivek Ragnekar, PhD
College: Medicine
Department/Division: Radiation Medicine
Title: Development of Vimentin Inhibitors for Secretion of Par-4 and Suppression of Tumor Metastasis

Principle Investigator: Dave Feola, PhD
College: Pharmacy
Department/Division: Pharmacy Practice & Science
Title: Novel immune-modulatory macrolides — discovery and function

CCTS Community Engagement
(7 Letters of Intent submitted; 7 applicants invited to submit full applications)

Principle Investigator: Christina Studts, PhD
College: Medicine
Department/Division: Behavioral Science
Title: Preventing Conduct Disorder: Valuing Parent & Provider Perspectives in Appalachia

MEDIA CONTACT: Mallory Powell, mallory.powell@uky.edu

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